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KMID : 0861020030180020129
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Korea Journal of Herbology
2003 Volume.18 No. 2 p.129 ~ p.134
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Effects of Benincasae Semen on Cultured Mouse Vascular Endotherial Cell Damaged by Glucose Oxidase
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Abstract
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Objectives : It has been demonstrated that oxidative stress of oxygen radicals is involved in vascular disorder. The aim of this study was to evaluate the cytotoxicity of glucose oxidase (GO) and protective effect of herb extract on GO-induced cytotoxicity in the cultured vascular endotherial cell (VEC) of mouse.
Methods : Cytotoxic effect of GO and protective effect of Benincasae Semen (BS) were performed by
MTT assay, after cultured VEC were incubated in the media containing 1-30 mU/ml GO for 6 hours.
Results : GO decreased cell viability in dose-and time-dependent mannner, and BS increased cell viability decreased by GO-induced cytotoxicity in these cultures.
Conclusion : From above the results, GO has cytotoxic effect, and herb extract, BS is very effective in blocking GO-induced cytotoxicity in cultured VEC.
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KEYWORD
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